Trifluoromethyl aldimines derived from a-amino esters have proven to be very good starting materials to obtain the title compounds. A Ag2O-catalyzed Mannich-type/cyclization cascade reaction starting from suitable a-isocyano acetates leads to enantiopure valuable trans-carboxylic trifluoromethyl substituted 2-imidazolines by a highly stereoselective addition without the need to add organocatalysts
Chiral trans-carboxylic trifluoromethyl 2-imidazolines by a Ag2O catalyzed Mannich-type reaction / Trulli, Laura; Sciubba, Fabio; Fioravanti, Stefania. - In: TETRAHEDRON. - ISSN 1464-5416. - STAMPA. - (2018), pp. 572-577. [10.1016/j.tet.2017.12.029]
Chiral trans-carboxylic trifluoromethyl 2-imidazolines by a Ag2O catalyzed Mannich-type reaction
Trulli, Laura;Sciubba, Fabio;Fioravanti, Stefania
2018
Abstract
Trifluoromethyl aldimines derived from a-amino esters have proven to be very good starting materials to obtain the title compounds. A Ag2O-catalyzed Mannich-type/cyclization cascade reaction starting from suitable a-isocyano acetates leads to enantiopure valuable trans-carboxylic trifluoromethyl substituted 2-imidazolines by a highly stereoselective addition without the need to add organocatalysts| File | Dimensione | Formato | |
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